Jörg Bungert, PhD
The work in Dr. Jörg Bunget’s laboratory focuses on analyzing the regulation of globin gene expression in red blood cells. The globin genes encode for components of hemoglobin. He and his lab use a combination of genetic and biochemical approaches to analyze the structure and function of the human b-globin locus control region (LCR), a powerful regulatory genetic element located far upstream of the globin genes. The LCR, which is composed of several sub-regions revealing high sensitivity to nucleases in erythroid cells enhances globin gene transcription in a developmental stage specific manner. They use transgenic mice, embryonic stem (ES) cell differentiation systems, and in vitro assays to elucidate the mechanism by which the LCR regulates the recruitment of transcription and chromatin modifying complexes to the b-globin gene locus.